GRB10 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:2887, GRB-IR, GRB10, Grb-10, HGNC:4564, IRBP, MEG1, MIM:601523, NM_001001549, NM_001001550, NM_001001555, NM_001350814, NM_001350815, NM_001350816, NM_001371008, NM_001371009, NM_005311, NP_001001549, NP_001001550, NP_001001555, NP_001337743, NP_001337744, NP_001337745, NP_001357937, NP_001357938, RSS, XM_011515316, XM_011515323, XM_017012029, XM_017012030, XM_017012031, XM_017012032, XM_017012033, XM_017012034, XM_017012036, XM_017012037, XM_017012038, XM_017012039, XM_017012040, XM_017012042, XM_017012043, XM_017012045, XM_017012046, XM_017012047, XM_017012048, XM_017012049, XM_017012050, XM_017012053, XM_017012054, XM_017012055, XM_017012056, XM_017012058, XM_017012059, XM_017012060, XM_017012061, XM_017012062, XM_017012063, XM_017012064, XM_017012065, XM_017012067, XM_017012068, XM_024446726, XM_024446728, XM_024446729, XM_024446730, XP_011513618, XP_011513625, XP_016867518, XP_016867519, XP_016867520, XP_016867521, XP_016867522, XP_016867523, XP_016867525, XP_016867526, XP_016867527, XP_016867528, XP_016867529, XP_016867531, XP_016867532, XP_016867534, XP_016867535, XP_016867536, XP_016867537, XP_016867538, XP_016867539, XP_016867542, XP_016867543, XP_016867544, XP_016867545, XP_016867547, XP_016867548, XP_016867549, XP_016867550, XP_016867551, XP_016867552, XP_016867553, XP_016867554, XP_016867556, XP_016867557, XP_024302494, XP_024302496, XP_024302497, XP_024302498, growth factor receptor bound protein 10

Omim:OMIM:601523

Id:ENSG00000106070

Hgnc:HGNC:4564

Entrez:2887

Ensembl:ENSG00000106070

Description:growth factor receptor bound protein 10

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View GRB10's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with GRB10.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using GRB10.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for GRB10.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with GRB10.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE179112 GSE179113 hydroxyl Hutt45 4 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE120612 etoposide leukocyte 7 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 4 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE179667 NVP-BEZ235 U-87MG Uppsala 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE115384 CELSR2 knockdown 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	Ataxia Phenotype (Entity type)	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...