HBP1 (Gene)

Entrez Gene ID: 26959

Description: HMG-box transcription factor 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HBP1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HBP1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HBP1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HBP1.

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Gene Sets (1370)

LINCS L1000 Chem Pert Consensus Sigs (490)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (4)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (143)

A gene set library provided by LINCS

rummageo gene perturbations (199)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (236)

A gene set library provided by LINCS

rummageo chemical perturbations (297)

A gene set library provided by LINCS

Knowledge Graph Assertions

Source	Relation	Target	Evidence
KIN001-043 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	-0.008563008
2-(1H-Indazol-4-yl)-6-(4-methanesul fonyl-piperazin-1-ylmethyl)-4-morph olin-4-yl-thieno[3,2-d]pyrimidine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.0046318937
5-(9-isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.008801636
9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.013420729
CHIR-99021 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	-0.010385114
TGX-115 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.009380563
4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.006956809
KFGENEBIN:HBP1-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)
1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.012169951
Deforolimus Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HBP1 Gene (Entity type)	0.010960358

KIN001-043
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
-0.008563008

2-(1H-Indazol-4-yl)-6-(4-methanesul fonyl-piperazin-1-ylmethyl)-4-morph olin-4-yl-thieno[3,2-d]pyrimidine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.0046318937

5-(9-isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.008801636

9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.013420729

CHIR-99021
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
-0.010385114

TGX-115
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.009380563

4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.006956809

KFGENEBIN:HBP1-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)

1-(4-{[4-(Dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.012169951

Deforolimus
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HBP1
Gene (Entity type)
0.010960358

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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.