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CFDE Workbench

HAMP (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:57817, HAMP, HEPC, HFE2B, HGNC:15598, LEAP1, MIM:606464, NM_021175, NP_066998, PLTR, hepcidin antimicrobial peptide
Omim:OMIM:606464
Id:ENSG00000105697
Hgnc:HGNC:15598
Entrez:57817
Ensembl:ENSG00000105697
Description:hepcidin antimicrobial peptide
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Oct 2014]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HAMP's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with HAMP.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HAMP.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HAMP.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HAMP.

Results found

Linked to

 

Label

Description

 

Gene Set

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

Gene Set

GSE151412 sorafenib 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE151412 2 V 1 SORAFENIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE234148 HDAC inhibition 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115542 digoxin 5 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE98856 adenosine 6 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE203329 HCC knockout 0 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE153871 cytarabine U2OS 1 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE218773 ABL2 knockdown Hep-G2 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    T60-Adrenal Consensus

    Gene Set (Entity type)

    A Gene Set from MoTrPAC

  • Gene Set

    GSE151412 sorafenib 2 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE151412 2 V 1 SORAFENIB HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE208350 H-7 Huh-7 JHH-7 0 v 8 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE234148 HDAC inhibition 3 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115542 digoxin 5 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE98856 adenosine 6 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE203329 HCC knockout 0 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE153871 cytarabine U2OS 1 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE218773 ABL2 knockdown Hep-G2 2 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.