ASAH1 (Gene)

Organism:

Homo sapiens

Synonyms:AC, ACDase, ASAH, ASAH1, ENTREZ:427, HGNC:735, MIM:613468, N-acylsphingosine amidohydrolase 1, NM_001127505, NM_001363743, NM_004315, NM_177924, NP_001120977, NP_001350672, NP_004306, NP_808592, PHP, PHP32, SMAPME, XM_005273504, XP_005273561

Omim:OMIM:613468

Id:ENSG00000104763

Hgnc:HGNC:735

Entrez:427

Ensembl:ENSG00000104763

Description:N-acylsphingosine amidohydrolase 1

This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. [provided by RefSeq, Oct 2015]

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View ASAH1's neighborhood in the knowledge graph.

Submit

Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with ASAH1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using ASAH1.

Submit

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for ASAH1.

Submit

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with ASAH1.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE118548 trametinib T84 1 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE110709 GSK-J4 5 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE195503 progesterone 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118548 1 V 2 TRAMETINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE118548 trametinib T84 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE214505 AKR1B1 knockdown A-549 3 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE214505 AKR1B1 knockdown A-549 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE110709 GSK-J4 5 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE182150 KIT LSD1 MYC inhibition 2 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE195503 progesterone 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE118548 1 V 2 TRAMETINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.