TIMP1 (Gene)

Entrez Gene ID: 7076

Description: TIMP metallopeptidase inhibitor 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TIMP1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TIMP1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TIMP1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TIMP1.

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Gene Sets (3448)

LINCS L1000 Chem Pert Consensus Sigs (816)

A gene set library provided by LINCS

GlyGen Glycosylated Proteins 2022 (58)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (2)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (958)

A gene set library provided by LINCS

rummageo gene perturbations (203)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (1)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (1072)

A gene set library provided by LINCS

rummageo chemical perturbations (326)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (2)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (10)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0027634355
Cyclobenzaprine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0046664854
N-[6-(2-aminoanilino)-6-oxo-hexyl]-4-methyl-benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	0.005485441
fluvoxamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0045371274
PF-04620110 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.004902569
(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(((3-(2-(5-tert-butyl-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0072979243
ZD-7288 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	0.004697675
Finasteride Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	0.0036984992
AZD-5069 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.0047955746
SA-1456102 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TIMP1 Gene (Entity type)	-0.015141403

6-(difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0027634355

Cyclobenzaprine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0046664854

N-[6-(2-aminoanilino)-6-oxo-hexyl]-4-methyl-benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
0.005485441

fluvoxamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0045371274

PF-04620110
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.004902569

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(((3-(2-(5-tert-butyl-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0072979243

ZD-7288
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
0.004697675

Finasteride
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
0.0036984992

AZD-5069
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.0047955746

SA-1456102
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TIMP1
Gene (Entity type)
-0.015141403

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Knowledge Graph Assertions

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.