WFDC2 (Gene)

Entrez Gene ID: 10406

Description: WAP four-disulfide core domain 2

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View WFDC2's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with WFDC2.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using WFDC2.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for WFDC2.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with WFDC2.

Gene Sets (4315)

LINCS L1000 Chem Pert Consensus Sigs (1113)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (15)

A gene set library provided by IDG

GlyGen Glycosylated Proteins 2022 (33)

A gene set library provided by GlyGen

KOMP2 Mouse Phenotypes 2022 (4)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (1061)

A gene set library provided by LINCS

rummageo gene perturbations (61)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (13)

A gene set library provided by GTEx

RummaGEO DrugPerturbations 2025 (162)

A gene set library provided by LINCS

LINCS L1000 Consensus Median Signatures (1747)

A gene set library provided by LINCS

rummageo chemical perturbations (92)

A gene set library provided by LINCS

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (3)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (11)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
KUC103424N Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.013326115
1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.005931988
K-788-2192 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	0.0068111126
Peruvoside Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.02074297
Amprenavir Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.012928413
Cinnarizine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.0028898218
omecamtiv-mecarbil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.005503337
N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	0.0044394974
[3H]-Palonosetron Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.003946532
3-{2-[2-(4-Methyl-piperidin-1-yl)-ethyl]-pyrrolidine-1-sulfonyl}-phenol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	WFDC2 Gene (Entity type)	-0.010404432

KUC103424N
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.013326115

1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.005931988

K-788-2192
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
0.0068111126

Peruvoside
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.02074297

Amprenavir
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.012928413

Cinnarizine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.0028898218

omecamtiv-mecarbil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.005503337

N-[2-(1,6,7,8-Tetrahydro-2H-3-oxa-as-indacen-8-yl)-ethyl]-propionamide(S)-(-)-22b
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
0.0044394974

[3H]-Palonosetron
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.003946532

3-{2-[2-(4-Methyl-piperidin-1-yl)-ethyl]-pyrrolidine-1-sulfonyl}-phenol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
WFDC2
Gene (Entity type)
-0.010404432

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Knowledge Graph Assertions

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.