MMP11 (Gene)

Organism:

Homo sapiens

Synonyms:ENTREZ:4320, HGNC:7157, MIM:185261, MMP11, NM_005940, NP_005931, NR_133013, SL-3, ST3, STMY3, matrix metallopeptidase 11

Omim:OMIM:185261

Id:ENSG00000099953

Hgnc:HGNC:7157

Entrez:4320

Ensembl:ENSG00000099953

Description:matrix metallopeptidase 11

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View MMP11's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with MMP11.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using MMP11.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for MMP11.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with MMP11.

Results found

Linked to

	Label	Description
	T60-Adrenal Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE218097 SOX10 overexpression glial cell 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	Ataxia Phenotype (Entity type)	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...
	GSE193993 SSTR2 knockout 1 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE118816 Myo1c knockdown podocyte 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE114013 GSE114014 itraconazole 0 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE74251 decitabine MCF-7 2 v 3 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE115384 CELSR2 knockdown 2 v 7 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE213588 trametinib NF1 10 v 6 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 10 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS

T60-Adrenal Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE218097 SOX10 overexpression glial cell 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

GSE193993 SSTR2 knockout 1 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE118816 Myo1c knockdown podocyte 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE114013 GSE114014 itraconazole 0 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE74251 decitabine MCF-7 2 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE115384 CELSR2 knockdown 2 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE213588 trametinib NF1 10 v 6 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 10 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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Community

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

This repository is under review for potential modification in compliance with Administration directives.