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CFDE Workbench

PGC (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:5225, HGNC:8890, MIM:169740, NM_001166424, NM_002630, NP_001159896, NP_002621, PEPC, PGC, PGII, progastricsin
Omim:OMIM:169740
Id:ENSG00000096088
Hgnc:HGNC:8890
Entrez:5225
Ensembl:ENSG00000096088
Description:progastricsin
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PGC's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PGC.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PGC.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PGC.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PGC.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE150895 GSE150896 enzalutamide 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE115384 CELSR2 knockdown 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE57871 vorinostat HCT 116 1 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 1 v 12 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE176403 GSE176404 LSD1 inhibition 1 v 3 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE153867 olaparib 6 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147876,GSE147877 2 V 10 ENZALUTAMIDE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE133927 PTEN p53 Meox1 knockdown BT-549 RNA Small Interfering 1 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147876 GSE147877 enzalutamide MR42D 2 v 10 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE77829 SLIRP knockdown LNCaP 3 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE150895 GSE150896 enzalutamide 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE115384 CELSR2 knockdown 2 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE57871 vorinostat HCT 116 1 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE57871 GLI1 PSMD13 knockdown HCT 116 Vorinostat 1 v 12 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE176403 GSE176404 LSD1 inhibition 1 v 3 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE153867 olaparib 6 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147876,GSE147877 2 V 10 ENZALUTAMIDE HUMAN UP

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.