CRISP3 (Gene)

Organism:

Homo sapiens

Synonyms:Aeg2, CRISP-3, CRISP3, CRS3, ENTREZ:10321, HGNC:16904, MIM:618062, NM_001190986, NM_001368123, NM_006061, NP_001177915, NP_001355052, NP_006052, SGP28, cysteine rich secretory protein 3, dJ442L6.3

Omim:OMIM:618062

Id:ENSG00000096006

Hgnc:HGNC:16904

Entrez:10321

Ensembl:ENSG00000096006

Description:cysteine rich secretory protein 3

This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View CRISP3's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with CRISP3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using CRISP3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for CRISP3.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with CRISP3.

Results found

Linked to

	Label	Description
	GSE176008 pyridoxine 4 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE176008 4 V 1 AZACITIDINE HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 13 v 11 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434 GSE202438 talazoparib 13 v 5 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE147876 GSE147877 enzalutamide MR42D 2 v 7 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 3 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE193258,GSE193259 9 V 15 OSIMERTINIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434,GSE202438 13 V 11 TALAZOPARIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS
	GSE202434,GSE202438 13 V 5 TALAZOPARIB HUMAN UP Gene Set (Entity type)	A Gene Set from LINCS

GSE176008 pyridoxine 4 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE245968 FOXA1 inhibition Receptors Steroid Acetyltransferases 3 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE176008 4 V 1 AZACITIDINE HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 13 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434 GSE202438 talazoparib 13 v 5 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE147876 GSE147877 enzalutamide MR42D 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 3 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE193258,GSE193259 9 V 15 OSIMERTINIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434,GSE202438 13 V 11 TALAZOPARIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

GSE202434,GSE202438 13 V 5 TALAZOPARIB HUMAN UP

Gene Set (Entity type)

A Gene Set from LINCS

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@CFDE Workbench 2026

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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