DOCK3 (Gene)

Organism:

Homo sapiens

Synonyms:DOCK3, ENTREZ:1795, HGNC:2989, MIM:603123, MOCA, NEDIDHA, NM_004947, NP_004938, PBP, XM_005264914, XM_005264915, XM_005264916, XM_005264917, XM_005264918, XM_006713008, XM_006713009, XM_006713010, XM_011533441, XM_011533443, XM_011533444, XM_011533445, XM_017005825, XM_017005826, XM_017005827, XM_017005828, XP_005264971, XP_005264972, XP_005264973, XP_005264974, XP_005264975, XP_006713071, XP_006713072, XP_006713073, XP_011531743, XP_011531745, XP_011531746, XP_011531747, XP_016861314, XP_016861315, XP_016861316, XP_016861317, dedicator of cytokinesis 3

Omim:OMIM:603123

Id:ENSG00000088538

Hgnc:HGNC:2989

Entrez:1795

Ensembl:ENSG00000088538

Description:dedicator of cytokinesis 3

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View DOCK3's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with DOCK3.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using DOCK3.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for DOCK3.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with DOCK3.

Results found

Linked to

	Label	Description
	GSE252944 AKT inhibition 7 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	Ataxia Phenotype (Entity type)	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...
	GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE228106 paclitaxel R1192 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE197422 GSE197424 FN1 overexpression HGC-27 1 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE128255 NDP knockdown stem cell 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE217452 docetaxel 2 v 1 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE214306 CCM1 knockout 5 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE238213 dopamine 2 v 4 human dn Gene Set (Entity type)	A Gene Set from LINCS

GSE252944 AKT inhibition 7 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE228106 paclitaxel R1192 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE197422 GSE197424 FN1 overexpression HGC-27 1 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE128255 NDP knockdown stem cell 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE217452 docetaxel 2 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE214306 CCM1 knockout 5 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE238213 dopamine 2 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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