RUNX1T1 (Gene)

Organism:

Homo sapiens

Synonyms:AML1-MTG8, AML1T1, CBFA2T1, CDR, ENTREZ:862, ETO, HGNC:1535, MIM:133435, MTG8, NM_001198625, NM_001198626, NM_001198627, NM_001198628, NM_001198629, NM_001198630, NM_001198631, NM_001198632, NM_001198633, NM_001198634, NM_001198679, NM_004349, NM_175634, NM_175635, NM_175636, NP_001185554, NP_001185555, NP_001185556, NP_001185557, NP_001185558, NP_001185559, NP_001185560, NP_001185561, NP_001185562, NP_001185563, NP_001185608, NP_004340, NP_783552, NP_783553, NP_783554, RUNX1 partner transcriptional co-repressor 1, RUNX1T1, XM_006716676, XM_011517351, XM_011517352, XM_011517353, XM_017013930, XM_017013932, XM_017013933, XM_017013934, XM_017013935, XM_017013936, XM_017013937, XM_017013938, XM_017013939, XM_017013940, XM_017013941, XM_024447317, XM_024447318, XP_006716739, XP_011515653, XP_011515654, XP_011515655, XP_016869419, XP_016869421, XP_016869422, XP_016869423, XP_016869424, XP_016869425, XP_016869426, XP_016869427, XP_016869428, XP_016869429, XP_016869430, XP_024303085, XP_024303086, XR_928359, ZMYND2

Omim:OMIM:133435

Nci:C28570

Id:ENSG00000079102

Hgnc:HGNC:1535

Entrez:862

Ensembl:ENSG00000079102

Description:RUNX1 partner transcriptional co-repressor 1

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View RUNX1T1's neighborhood in the knowledge graph.

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Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with RUNX1T1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using RUNX1T1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for RUNX1T1.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with RUNX1T1.

Results found

Linked to

	Label	Description
	T61-Colon Consensus Gene Set (Entity type)	A Gene Set from MoTrPAC
	GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE118816 Myo1c knockdown podocyte 0 v 1 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE195503 progesterone 3 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE184892 trehalose fibroblast 4 v 2 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE156648 DOT1L overexpression IMR-90 2 v 3 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE252944 AKT inhibition 3 v 0 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 ADIPOR2 knockout HEK293 0 v 9 human dn Gene Set (Entity type)	A Gene Set from LINCS
	GSE102505 tunicamycin 6 v 0 human up Gene Set (Entity type)	A Gene Set from LINCS
	GSE158834 ADIPOR2 knockout HEK293 0 v 8 human dn Gene Set (Entity type)	A Gene Set from LINCS

T61-Colon Consensus

Gene Set (Entity type)

A Gene Set from MoTrPAC

GSE228619 cadherin-11 CDH11 knockdown RNA Small Interfering 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE118816 Myo1c knockdown podocyte 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE195503 progesterone 3 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE184892 trehalose fibroblast 4 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE156648 DOT1L overexpression IMR-90 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE252944 AKT inhibition 3 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 ADIPOR2 knockout HEK293 0 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

GSE102505 tunicamycin 6 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

GSE158834 ADIPOR2 knockout HEK293 0 v 8 human dn

Gene Set (Entity type)

A Gene Set from LINCS

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

Consortium

Community

Resources

CFDE Workbench

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2026

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