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TYR (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ATN, CMM8, ENTREZ:7299, HGNC:12442, MIM:606933, NM_000372, NP_000363, OCA1, OCA1A, OCAIA, SHEP3, TYR, XM_011542970, XP_011541272, tyrosinase
Omim:OMIM:606933
Id:ENSG00000077498
Hgnc:HGNC:12442
Entrez:7299
Ensembl:ENSG00000077498
Description:tyrosinase
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TYR's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with TYR.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TYR.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TYR.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TYR.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE213588 trametinib NF1 8 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE156761 dopamine neuron 0 v 4 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE174745 dopamine neuron 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213588 8 V 7 TRAMETINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE199688 artemisinin 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE156761 dopamine neuron 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE174745 dopamine neuron 1 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Phenotype

Sensorineural hearing impairment

Phenotype (Entity type)

A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

Gene Set

GSE234514 GSE234516 palbociclib 2 v 3 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE213588 trametinib NF1 8 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE213588 trametinib NF1 8 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE156761 dopamine neuron 0 v 4 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE174745 dopamine neuron 1 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213588 8 V 7 TRAMETINIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE199688 artemisinin 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE156761 dopamine neuron 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE174745 dopamine neuron 1 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Phenotype

    Sensorineural hearing impairment

    Phenotype (Entity type)

    A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlea...

  • Gene Set

    GSE234514 GSE234516 palbociclib 2 v 3 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE213588 trametinib NF1 8 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.