Synonyms:ENTREZ:9448, FLH21957, HEL-S-31, HGK, HGNC:6866, MAP4K4, MEKKK4, MIM:604666, NIK, NM_001242559, NM_001242560, NM_001384476, NM_001384477, NM_001384478, NM_001384481, NM_001384482, NM_001384483, NM_001384484, NM_001384485, NM_001384486, NM_001384487, NM_001384488, NM_001384490, NM_001384491, NM_001384492, NM_001384493, NM_001384494, NM_001384495, NM_001384496, NM_001384497, NM_001384506, NM_001384507, NM_001384508, NM_001384509, NM_001384520, NM_001384543, NM_001384548, NM_001384549, NM_001384550, NM_001384551, NM_001384552, NM_001384553, NM_001384554, NM_001384555, NM_001384556, NM_001384557, NM_001384558, NM_001384559, NM_001384560, NM_001384561, NM_001384562, NM_001384563, NM_001384564, NM_001384567, NM_001384572, NM_001384579, NM_004834, NM_145686, NM_145687, NP_001229488, NP_001229489, NP_001371405, NP_001371406, NP_001371407, NP_001371410, NP_001371411, NP_001371412, NP_001371413, NP_001371414, NP_001371415, NP_001371416, NP_001371417, NP_001371419, NP_001371420, NP_001371421, NP_001371422, NP_001371423, NP_001371424, NP_001371425, NP_001371426, NP_001371435, NP_001371436, NP_001371437, NP_001371438, NP_001371449, NP_001371472, NP_001371477, NP_001371478, NP_001371479, NP_001371480, NP_001371481, NP_001371482, NP_001371483, NP_001371484, NP_001371485, NP_001371486, NP_001371487, NP_001371488, NP_001371489, NP_001371490, NP_001371491, NP_001371492, NP_001371493, NP_001371496, NP_001371501, NP_001371508, NP_004825, NP_663719, NP_663720, NR_169279, NR_169280, NR_169281, NR_169282, XM_005264048, XM_005264050, XM_005264052, XM_005264057, XM_005264059, XM_005264060, XM_005264062, XM_005264063, XM_005264065, XM_005264066, XM_005264068, XM_005264069, XM_005264071, XM_006712865, XM_017005351, XM_017005354, XM_017005356, XM_017005357, XM_017005358, XM_017005360, XM_017005363, XM_017005366, XM_017005368, XM_017005369, XM_017005371, XM_017005372, XM_017005373, XP_005264105, XP_005264107, XP_005264109, XP_005264114, XP_005264116, XP_005264117, XP_005264119, XP_005264120, XP_005264122, XP_005264123, XP_005264125, XP_005264126, XP_005264128, XP_006712928, XP_016860840, XP_016860843, XP_016860845, XP_016860846, XP_016860847, XP_016860849, XP_016860852, XP_016860855, XP_016860857, XP_016860858, XP_016860860, XP_016860861, XP_016860862, mitogen-activated protein kinase kinase kinase kinase 4
Omim:OMIM:604666
Id:ENSG00000071054
Hgnc:HGNC:6866
Description:mitogen-activated protein kinase kinase kinase kinase 4
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
