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CFDE Workbench

PIK3CB (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:5291, HGNC:8976, MIM:602925, NM_001256045, NM_006219, NP_001242974, NP_006210, P110BETA, PI3K, PI3KBETA, PIK3C1, PIK3CB, XM_006713659, XM_011512895, XM_017006619, XM_017006621, XM_024453596, XM_024453597, XP_006713722, XP_011511197, XP_016862108, XP_016862110, XP_024309364, XP_024309365, XR_002959542, phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit beta
Omim:OMIM:602925
Id:ENSG00000051382
Hgnc:HGNC:8976
Entrez:5291
Ensembl:ENSG00000051382
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

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Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View PIK3CB's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with PIK3CB.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using PIK3CB.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for PIK3CB.

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Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with PIK3CB.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE163297 doxorubicin 0 v 2 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Phenotype

Ataxia

Phenotype (Entity type)

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

Gene Set

GSE119978 GSE180930 cisplatin 3 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE164874 prednisolone muscle organ 5 v 9 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 13 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE161800 cisplatin A-549 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE111247 temozolomide LN-308 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE163297 doxorubicin 0 v 2 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Phenotype

    Ataxia

    Phenotype (Entity type)

    Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of el...

  • Gene Set

    GSE119978 GSE180930 cisplatin 3 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE248770 STIM1 knockout Hep 3B2.1-7 Sorafenib 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE248770 sorafenib Hep 3B2.1-7 0 v 1 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE233647 docetaxel UFERSA-PC3 DU145 2 v 0 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE164874 prednisolone muscle organ 5 v 9 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 13 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE161800 cisplatin A-549 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE111247 temozolomide LN-308 2 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Consortium
    About the CFDECF ProgramsCFDE CentersPartnershipsPilot Projects
    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.