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HSD17B6 (Gene)

Ensembl Gene ID: ENSG00000025423

Entrez Gene ID: 8630

Description: hydroxysteroid 17-beta dehydrogenase 6

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View HSD17B6's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with HSD17B6.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using HSD17B6.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for HSD17B6.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	tolazoline Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	-0.0069186147
	HSD17B6 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	NADP Metabolite (Entity type)
	2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	-0.0029550197
	HSD17B6 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	androstenedione Metabolite (Entity type)
	tyloxapol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	-0.017064743
	HSD17B6 Gene (Entity type)	Causally influences Knowledge Graph Relation (Entity type)	all-trans-retinol Metabolite (Entity type)
	SA-1920683 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	-0.009862796
	KFGENEBIN:HSD17B6-variant-count CUI KFGENEBIN (Entity type)	Gene has variants Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)
	SA-1462246 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	0.013806111
	tribenoside Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HSD17B6 Gene (Entity type)	0.008923268

tolazoline
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
-0.0069186147

HSD17B6
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
NADP
Metabolite (Entity type)

2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
-0.0029550197

HSD17B6
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
androstenedione
Metabolite (Entity type)

tyloxapol
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
-0.017064743

HSD17B6
Gene (Entity type)
Causally influences
Knowledge Graph Relation (Entity type)
all-trans-retinol
Metabolite (Entity type)

SA-1920683
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
-0.009862796

KFGENEBIN:HSD17B6-variant-count CUI
KFGENEBIN (Entity type)
Gene has variants
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)

SA-1462246
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
0.013806111

tribenoside
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HSD17B6
Gene (Entity type)
0.008923268

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