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CFDE Workbench

LTF (Gene)

Organism:

Homo sapiens

Taxonomy (Entity type)
Synonyms:ENTREZ:4057, GIG12, HEL110, HGNC:6720, HLF2, LF, LTF, MIM:150210, NM_001199149, NM_001321121, NM_001321122, NM_002343, NP_001186078, NP_001308050, NP_001308051, NP_002334, lactotransferrin
Omim:OMIM:150210
Id:ENSG00000012223
Hgnc:HGNC:6720
Entrez:4057
Ensembl:ENSG00000012223
Description:lactotransferrin
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]

Analyze

Data Distillery
CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View LTF's neighborhood in the knowledge graph.

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Playbook Workflow Builder
Playbook Workflow Builder: Gene-Centric Workflow

View Gene-Centric information about the gene from a pre-built PWB workflow. View the workflow with LTF.

Gene Partnership Appyter
CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using LTF.

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Gene and Drug Landing Page Aggregator
GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for LTF.

Submit
Playbook Workflow Builder
Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with LTF.

Results found

Linked to

 

Label

Description

 

Gene Set

GSE239844 crizotinib 11 v 9 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE228106 paclitaxel R1192 0 v 1 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE114013 GSE114014 itraconazole 0 v 4 human dn

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE102505 tunicamycin 6 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE206931 WDR5 inhibition WIN 8 v 7 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE239844 11 V 9 CRIZOTINIB HUMAN DN

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 13 v 11 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE153871 cytarabine U2OS 1 v 2 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE202434 GSE202438 talazoparib 4 v 0 human up

Gene Set (Entity type)

A Gene Set from LINCS

Gene Set

GSE147876 GSE147877 enzalutamide MR42D 2 v 7 human dn

Gene Set (Entity type)

A Gene Set from LINCS

  • Gene Set

    GSE239844 crizotinib 11 v 9 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE228106 paclitaxel R1192 0 v 1 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE114013 GSE114014 itraconazole 0 v 4 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE102505 tunicamycin 6 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE206931 WDR5 inhibition WIN 8 v 7 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE239844 11 V 9 CRIZOTINIB HUMAN DN

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 13 v 11 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE153871 cytarabine U2OS 1 v 2 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE202434 GSE202438 talazoparib 4 v 0 human up

    Gene Set (Entity type)

    A Gene Set from LINCS

  • Gene Set

    GSE147876 GSE147877 enzalutamide MR42D 2 v 7 human dn

    Gene Set (Entity type)

    A Gene Set from LINCS

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    Community
    Workbench TutorialTraining & OutreachDocumentationGet QR CodesFunding Opportunities
    Resources
    Data & MetadataToolsChatbotUse CasesPublications
    CFDE Workbench
    Report a bug
    The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.
    @CFDE Workbench 2026
    This repository is under review for potential modification in compliance with Administration directives.