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TKTL1 (Gene)

Ensembl Gene ID: ENSG00000007350

Entrez Gene ID: 8277

Description: transketolase like 1

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View TKTL1's neighborhood in the knowledge graph.

Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with TKTL1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using TKTL1.

GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for TKTL1.

Gene Sets (2185)

LINCS L1000 Chem Pert Consensus Sigs (689)

A gene set library provided by LINCS

Illuminating the Druggable Genome

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (464)

A gene set library provided by LINCS

rummageo gene perturbations (43)

A gene set library provided by LINCS

Genotype Tissue Expression

GTEx Aging Signatures 2021 (12)

A gene set library provided by GTEx

LINCS L1000 Consensus Median Signatures (900)

A gene set library provided by LINCS

rummageo chemical perturbations (72)

A gene set library provided by LINCS

Genotype Tissue Expression

GTEx Tissues V8 2023 (3)

A gene set library provided by GTEx

Illuminating the Druggable Genome

IDG Drug Targets 2022 (1)

A gene set library provided by IDG

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	dofetilide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.0041186106
	2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	0.011857831
	8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	0.005050031
	octopamine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.010886988
	5-(4,4-dimethyl-2-thioxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.0037881373
	Thiostrepton Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.011184042
	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.0043783886
	HLI-373 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	0.006062826
	NK26-I-41-1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.0090818405
	AG-592 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TKTL1 Gene (Entity type)	-0.0128751965

dofetilide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.0041186106

2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
0.011857831

8-(dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
0.005050031

octopamine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.010886988

5-(4,4-dimethyl-2-thioxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.0037881373

Thiostrepton
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.011184042

4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.0043783886

HLI-373
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
0.006062826

NK26-I-41-1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.0090818405

AG-592
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TKTL1
Gene (Entity type)
-0.0128751965

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Community

Resources

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2025

This repository is under review for potential modification in compliance with Administration directives.