KEAP1 (Gene)

Description: kelch like ECH associated protein 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View KEAP1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with KEAP1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using KEAP1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for KEAP1.

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Gene Sets (329)

LINCS L1000 Chem Pert Consensus Sigs (239)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (4)

A gene set library provided by IDG

LINCS L1000 CRISPR KO Consensus Sigs (82)

A gene set library provided by LINCS

GTEx Tissues V8 2023 (4)

A gene set library provided by GTEx

Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-hydroxy-7-(2-((2'-methylbiphenyl-4-yl)methylene)hydrazinyl)-7-oxoheptanamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.018186761
WT-171 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.02000763
WZ4002 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	0.0024272287
Rocilinostat Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.005446917
N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.016764743
BADGE Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	0.012784484
tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxo-heptyl]carbamoyl]isoxazol-5-yl]phenyl]carbamate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.038664717
droxinostat Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.012817784
4-(dimethylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	-0.020649785
parthenolide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KEAP1 Gene (Entity type)	0.006049668