SIK1 (Gene)

Description: salt inducible kinase 1

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View SIK1's neighborhood in the knowledge graph.

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Playbook Workflow Builder

The Playbook Workflow Builder helps you interactively construct workflows leveraging CFDE APIs without code. Start a new workflow with SIK1.

CFDE Gene-Centric Appyter

The CFDE Gene Centric Appyter Resolves and Displays Gene-Centric information from CFDE APIs. Execute the Appyter using SIK1.

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GDLPA Landing Pages Links

The Gene and Drug Landing Page Aggregator (GDLPA) finds links to primary and secondary source information from CFDE and other resources. Discover landing pages for SIK1.

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Gene Sets (2796)

LINCS L1000 Chem Pert Consensus Sigs (1334)

A gene set library provided by LINCS

ARCHS4 IDG Coexp (1)

A gene set library provided by IDG

KOMP2 Mouse Phenotypes 2022 (5)

A gene set library provided by KOMP2

LINCS L1000 CRISPR KO Consensus Sigs (1408)

A gene set library provided by LINCS

GTEx Aging Signatures 2021 (33)

A gene set library provided by GTEx

Molecular Transducers of Physical Activity Consortium

MoTrPAC Endurance Trained Rats 2023 (4)

A gene set library provided by MoTrPAC

GTEx Tissues V8 2023 (1)

A gene set library provided by GTEx

IDG Drug Targets 2022 (10)

A gene set library provided by IDG

Knowledge Graph Assertions

Source	Relation	Target	Evidence
SID11113856 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.010608917
2-[(S)-4-(4-Chloro-phenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-N-(4-hydroxy-phenyl)acetamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	0.011233324
Valdecoxib Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.003352898
SID11113364 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.0033711798
SID11113879 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	0.005742253
Clobetasol propionate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	0.00908505
Formestane Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.0036455477
SID11113947 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.009829732
4-(3'-Fluorophenethyl)-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.0059271716
1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SIK1 Gene (Entity type)	-0.005046482