High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
6-{1-[3-(2-fluoro-5-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
6-[(3-phenoxyazetidin-1-yl)(phenyl)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
US8822479, 34 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
6-{1-[3-(3-chloro-4-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
1-cyclopentyl-6-{(1R)-1-[3-(4-methoxyphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
1-cyclopentyl-6-{(1R)-1-[3-(2-methylpyrimidin-4-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
US8623901, 224 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
6-{1-[3-(pyrimidin-4-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50
(R)-2-(1-cyclopentyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-N-(4-methoxyphenyl)propanamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein (Entity type)	IC50

3-isopropyl-5-{[(1S,2R)-2-(2-morpholin-4-ylethoxy)cyclohexyl]methyl}-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

6-{1-[3-(2-fluoro-5-methylphenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

6-[(3-phenoxyazetidin-1-yl)(phenyl)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

US8822479, 34
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

6-{1-[3-(3-chloro-4-fluorophenoxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, trifluoroacetate salt
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

1-cyclopentyl-6-{(1R)-1-[3-(4-methoxyphenoxy)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

1-cyclopentyl-6-{(1R)-1-[3-(2-methylpyrimidin-4-yl)azetidin-1-yl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

US8623901, 224
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

6-{1-[3-(pyrimidin-4-yloxy)azetidin-1-yl]ethyl}-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

(R)-2-(1-cyclopentyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-N-(4-methoxyphenyl)propanamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein (Entity type)
IC50

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