Glucagon receptor (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Glucagon receptor 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-(4-(1-(3-(4-cyanophenyl)-6-(4-(trifluoromethoxy)phenyl)-1H-indazol-1-yl)ethyl)benzamido)propanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	IC50
3-[[4-[(1S)-3-methyl-1-[6-methyl-5-[2-methyl-4-(trifluoromethyl)phenyl]indazol-2-yl]butyl]benzoyl]amino]propanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	Ki
(3S,6S,9S,12S,15S,18S,21S)-3-((2S,5S,8S,11S,14S,17R,20S,23S,26S,29S,32S,35S,38S,41S,42R)-29-((1H-indol-3-yl)methyl)-38-(2-amino-2-oxoethyl)-14,26-bis(3-amino-3-oxopropyl)-20-benzyl-41-carbamoyl-5,8-bis(3-guanidinopropyl)-1,42-dihydroxy-32-isobutyl-23-isopropyl-17-(mercaptomethyl)-11-methyl-35-(2-(methylthio)ethyl)-3,6,9,12,15,18,21,24,27,30,33,36,39-tridecaoxo-4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaazatritetracontan-2-ylcarbamoyl)-21-((2S,5S,8S,11S,17S,20S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2,20-bis(hydroxymethyl)-24-(1H-imidazol-5-yl)-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-12-(4-aminobutyl)-9,18-bis(4-hydroxybenzyl)-15-(hydroxymethyl)-6-isobutyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	EC50
(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42S,45S,48S)-3-((2S,5S,8S,11S,17S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2-(hydroxymethyl)-24-(1H-imidazol-5-yl)-20,20-dimethyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-48-((8S,14S,17S)-1-((S)-2-((S)-1-((S)-1-(2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-1-amino-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-2-oxoethylamino)-3-hydroxy-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidin-1-yl)-18-(1H-indol-3-yl)-14-isobutyl-8,11,11-trimethyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaoctadecan-17-ylcarbamoyl)-15,27-bis(3-amino-3-oxopropyl)-12,36-bis(4-aminobutyl)-42-benzyl-45-sec-butyl-24-(2-carboxyethyl)-21-(carboxymethyl)-30-(3-guanidinopropyl)-9-(hydroxymethyl)-6,18,39-triisobutyl-33-methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-pentadecaoxo-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-pentadecaazahenpentacontane-1,51-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	EC50
(R*)-3-(4-(3-methyl-1-(5-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)butyl)benzamido)propanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	Ki
(3S,6S,9S,12S,15R,18S,21S,24S,27S,30S,33S,36S,39S)-3-((2S,5S,8S,11S,14S,17S,20S,23S,24R)-11-((1H-indol-3-yl)methyl)-20-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-23-carbamoyl-24-hydroxy-14-isobutyl-5-isopropyl-17-(2-(methylthio)ethyl)-3,6,9,12,15,18,21-heptaoxo-1-phenyl-4,7,10,13,16,19,22-heptaazapentacosan-2-ylcarbamoyl)-39-((2S,5S,8S,11S,17S,20S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2,20-bis(hydroxymethyl)-24-(1H-imidazol-5-yl)-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-6-(3-amino-3-oxopropyl)-30-(4-aminobutyl)-21-(carboxymethyl)-12-(3-guanidinopropyl)-15-((1-hexadecyl-2,5-dioxopyrrolidin-3-ylthio)methyl)-27,36-bis(4-hydroxybenzyl)-18,33-bis(hydroxymethyl)-24-isobutyl-9-methyl-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxo-4,7,10,13,16,19,22,25,28,31,34,37-dodecaazahentetracontane-1,41-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	EC50
3-[4-({(9H-Fluoren-2-yl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic Acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	IC50
3-(4-(1-(5-(6-Methoxynaphthalen-2-yl)-4-methyl-3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)ethyl)benzamido)propanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	IC50
(S)-3-(4-(2-(5-chloro-1-(3-(trifluoromethyl)phenyl)-1H-indole-2-carbonyl)hexyl)benzamido)propanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	IC50
US8748624, 112 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Glucagon receptor Protein (Entity type)	Ki

3-(4-(1-(3-(4-cyanophenyl)-6-(4-(trifluoromethoxy)phenyl)-1H-indazol-1-yl)ethyl)benzamido)propanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
IC50

3-[[4-[(1S)-3-methyl-1-[6-methyl-5-[2-methyl-4-(trifluoromethyl)phenyl]indazol-2-yl]butyl]benzoyl]amino]propanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
Ki

(3S,6S,9S,12S,15S,18S,21S)-3-((2S,5S,8S,11S,14S,17R,20S,23S,26S,29S,32S,35S,38S,41S,42R)-29-((1H-indol-3-yl)methyl)-38-(2-amino-2-oxoethyl)-14,26-bis(3-amino-3-oxopropyl)-20-benzyl-41-carbamoyl-5,8-bis(3-guanidinopropyl)-1,42-dihydroxy-32-isobutyl-23-isopropyl-17-(mercaptomethyl)-11-methyl-35-(2-(methylthio)ethyl)-3,6,9,12,15,18,21,24,27,30,33,36,39-tridecaoxo-4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaazatritetracontan-2-ylcarbamoyl)-21-((2S,5S,8S,11S,17S,20S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2,20-bis(hydroxymethyl)-24-(1H-imidazol-5-yl)-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-12-(4-aminobutyl)-9,18-bis(4-hydroxybenzyl)-15-(hydroxymethyl)-6-isobutyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
EC50

(3S,6S,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S,42S,45S,48S)-3-((2S,5S,8S,11S,17S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2-(hydroxymethyl)-24-(1H-imidazol-5-yl)-20,20-dimethyl-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-48-((8S,14S,17S)-1-((S)-2-((S)-1-((S)-1-(2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-1-amino-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-2-oxoethylamino)-3-hydroxy-1-oxopropan-2-ylamino)-3-hydroxy-1-oxopropan-2-ylcarbamoyl)pyrrolidin-1-yl)-18-(1H-indol-3-yl)-14-isobutyl-8,11,11-trimethyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaoctadecan-17-ylcarbamoyl)-15,27-bis(3-amino-3-oxopropyl)-12,36-bis(4-aminobutyl)-42-benzyl-45-sec-butyl-24-(2-carboxyethyl)-21-(carboxymethyl)-30-(3-guanidinopropyl)-9-(hydroxymethyl)-6,18,39-triisobutyl-33-methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-pentadecaoxo-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-pentadecaazahenpentacontane-1,51-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
EC50

(R*)-3-(4-(3-methyl-1-(5-(4-(trifluoromethyl)phenyl)-1H-indazol-1-yl)butyl)benzamido)propanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
Ki

(3S,6S,9S,12S,15R,18S,21S,24S,27S,30S,33S,36S,39S)-3-((2S,5S,8S,11S,14S,17S,20S,23S,24R)-11-((1H-indol-3-yl)methyl)-20-(2-amino-2-oxoethyl)-8-(3-amino-3-oxopropyl)-23-carbamoyl-24-hydroxy-14-isobutyl-5-isopropyl-17-(2-(methylthio)ethyl)-3,6,9,12,15,18,21-heptaoxo-1-phenyl-4,7,10,13,16,19,22-heptaazapentacosan-2-ylcarbamoyl)-39-((2S,5S,8S,11S,17S,20S,23S)-23-amino-17-(3-amino-3-oxopropyl)-8-benzyl-5,11-bis((R)-1-hydroxyethyl)-2,20-bis(hydroxymethyl)-24-(1H-imidazol-5-yl)-4,7,10,13,16,19,22-heptaoxo-3,6,9,12,15,18,21-heptaazatetracosanamido)-6-(3-amino-3-oxopropyl)-30-(4-aminobutyl)-21-(carboxymethyl)-12-(3-guanidinopropyl)-15-((1-hexadecyl-2,5-dioxopyrrolidin-3-ylthio)methyl)-27,36-bis(4-hydroxybenzyl)-18,33-bis(hydroxymethyl)-24-isobutyl-9-methyl-5,8,11,14,17,20,23,26,29,32,35,38-dodecaoxo-4,7,10,13,16,19,22,25,28,31,34,37-dodecaazahentetracontane-1,41-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
EC50

3-[4-({(9H-Fluoren-2-yl)-[4-(4-trifluoromethoxyphenyl)thiazol-2-yl]amino}methyl)benzoylamino]propionic Acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
IC50

3-(4-(1-(5-(6-Methoxynaphthalen-2-yl)-4-methyl-3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)ethyl)benzamido)propanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
IC50

(S)-3-(4-(2-(5-chloro-1-(3-(trifluoromethyl)phenyl)-1H-indole-2-carbonyl)hexyl)benzamido)propanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
IC50

US8748624, 112
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Glucagon receptor
Protein (Entity type)
Ki

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