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Insulin receptor (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Insulin receptor 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	7-{5-Chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-1-ethyl-8-methoxy-1,3,4,5-tetrahydro-benzo[b]azepin-2-one Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	(1S,2S,3R,4R)-3-(5-chloro-2-(1-ethyl-6-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)pyrimidin-4-ylamino)bicyclo[2.2.1]hept-5-ene-2-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	(5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S)-20-((1H-indol-3-yl)methyl)-38-((3S,9S,12S)-1-((S)-1-((2R,8S,14S,17S,20S,23R,26S,29S,32S,35S,38S,41S,44S,47S,50S,53S)-38-((1H-indol-3-yl)methyl)-53-amino-32-(3-amino-3-oxopropyl)-20,26,41,44,47-pentakis(2-carboxyethyl)-8-(3-guanidinopropyl)-54-hydroxy-14-(4-hydroxybenzyl)-50-isobutyl-17,29-diisopropyl-2,23-bis(mercaptomethyl)-35-methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-heptadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-heptadecaazatetrapentacontane)pyrrolidin-2-yl)-3,9-bis(hydroxymethyl)-12-isobutyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecanamido)-8-(3-amino-3-oxopropyl)-17,29-dibenzyl-14,35-bis(2-carboxyethyl)-23-(carboxymethyl)-11-(3-guanidinopropyl)-26-(4-hydroxybenzyl)-32-(hydroxymethyl)-5-isobutyl-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxo-3,6,9,12,15,18,21,24,27,30,33,36-dodecaazatetracontane-1,40-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	Kd
	2-(4-(dimethylamino)styryl)-3,6-dimethylbenzo[d]thiazol-3-ium Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	5-chloro-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-N4-(2-methoxyphenyl)pyrimidine-2,4-diamine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	2-fluoro-6-(2-(4-(4-isopropylpiperazin-1-yl)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	SID103904601 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	Ki
	3-benzyl-2-(4-(dimethylamino)styryl)benzo[d]thiazol-3-ium Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl)pyrimidine-2,4-diamine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50
	2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Insulin receptor Protein (Entity type)	IC50

7-{5-Chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-1-ethyl-8-methoxy-1,3,4,5-tetrahydro-benzo[b]azepin-2-one
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

(1S,2S,3R,4R)-3-(5-chloro-2-(1-ethyl-6-methoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)pyrimidin-4-ylamino)bicyclo[2.2.1]hept-5-ene-2-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

(5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S)-20-((1H-indol-3-yl)methyl)-38-((3S,9S,12S)-1-((S)-1-((2R,8S,14S,17S,20S,23R,26S,29S,32S,35S,38S,41S,44S,47S,50S,53S)-38-((1H-indol-3-yl)methyl)-53-amino-32-(3-amino-3-oxopropyl)-20,26,41,44,47-pentakis(2-carboxyethyl)-8-(3-guanidinopropyl)-54-hydroxy-14-(4-hydroxybenzyl)-50-isobutyl-17,29-diisopropyl-2,23-bis(mercaptomethyl)-35-methyl-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52-heptadecaoxo-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51-heptadecaazatetrapentacontane)pyrrolidin-2-yl)-3,9-bis(hydroxymethyl)-12-isobutyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazatridecanamido)-8-(3-amino-3-oxopropyl)-17,29-dibenzyl-14,35-bis(2-carboxyethyl)-23-(carboxymethyl)-11-(3-guanidinopropyl)-26-(4-hydroxybenzyl)-32-(hydroxymethyl)-5-isobutyl-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxo-3,6,9,12,15,18,21,24,27,30,33,36-dodecaazatetracontane-1,40-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
Kd

2-(4-(dimethylamino)styryl)-3,6-dimethylbenzo[d]thiazol-3-ium
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

5-chloro-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-N4-(2-methoxyphenyl)pyrimidine-2,4-diamine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

2-fluoro-6-(2-(4-(4-isopropylpiperazin-1-yl)-2-methoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

SID103904601
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
Ki

3-benzyl-2-(4-(dimethylamino)styryl)benzo[d]thiazol-3-ium
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrazino[2,1-a]isoquinolin-9-yl)pyrimidine-2,4-diamine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-methyl-benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Insulin receptor
Protein (Entity type)
IC50

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