Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-5,9-dihydroxy-4-methoxy-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-[({[2-({2-methoxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}formamido)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
tautomycin diacid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-5,9-dihydroxy-4-methoxy-12-[(2S,3S,6R,8S,9R)-8-[(3S,4Z)-4-[({[2-({2-methoxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}formamido)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
Calyculin A Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	IC50
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-({[(3-benzoylphenyl)carbamoyl]methoxy}imino)-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-[6-methoxy-3,5-dimethyl-7-phenyl-(1E,3E)-1,3-heptadienyl]-4,11,18,22-tetramethyl-21-methylene-3,7,10,14,17,20,23-heptaoxo-2,6,9,13,16,19,22-heptaazacyclopentacosane-1,12-dicarboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	IC50
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4Z)-4-[({[2-({2-[(3-azido-4-fluorophenyl)formamido]ethyl}disulfanyl)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-{[({2-[(3-azido-4-fluorophenyl)formamido]ethyl}carbamoyl)methoxy]imino}-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki
Tautomycetin Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	IC50
(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-[({[2-({2-[(3-azido-4-fluorophenyl)formamido]ethyl}disulfanyl)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Protein (Entity type)	Ki

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-5,9-dihydroxy-4-methoxy-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-[({[2-({2-methoxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}formamido)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

tautomycin diacid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-5,9-dihydroxy-4-methoxy-12-[(2S,3S,6R,8S,9R)-8-[(3S,4Z)-4-[({[2-({2-methoxy-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl}formamido)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

Calyculin A
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
IC50

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-({[(3-benzoylphenyl)carbamoyl]methoxy}imino)-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-[6-methoxy-3,5-dimethyl-7-phenyl-(1E,3E)-1,3-heptadienyl]-4,11,18,22-tetramethyl-21-methylene-3,7,10,14,17,20,23-heptaoxo-2,6,9,13,16,19,22-heptaazacyclopentacosane-1,12-dicarboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
IC50

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4Z)-4-[({[2-({2-[(3-azido-4-fluorophenyl)formamido]ethyl}disulfanyl)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-{[({2-[(3-azido-4-fluorophenyl)formamido]ethyl}carbamoyl)methoxy]imino}-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

Tautomycetin
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
IC50

(2Z)-2-[(1R)-3-{[(3R,4S,5R,8S,9S,12R)-12-[(2S,3S,6R,8S,9R)-8-[(3S,4E)-4-[({[2-({2-[(3-azido-4-fluorophenyl)formamido]ethyl}disulfanyl)ethyl]carbamoyl}methoxy)imino]-3-methylpentyl]-3,9-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-5,9-dihydroxy-4-methoxy-2,8-dimethyl-7-oxotridecan-3-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Protein (Entity type)
Ki

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