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Heparanase (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Heparanase 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	2-{5-[5-(3,4-Difluoro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	tetradecasodium[(2R,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6R)-6-[(2R,3R,4S,5R,6R)-6-[(2R,3R,4S,5R,6R)-6-[[(4R)-4-[(3S,5S,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-10,13-dimethyl-3-sulfonatooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)tetrahydropyran-4-yl]sulfate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	Ki
	2-{5-[5-(3-Chloro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	3beta-cholestanyl 2,3,4,6-tetra-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-beta-D-glucopyranoside, tridecasodium salt Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	Ki
	8-(5-Dimethylaminonaphthalene-1-sulfonamido)octyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->2)-3,4,6-tri-O-sulfo-alpha-D-mannopyranoside, Tridecasodium Salt Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	Kd
	N-(4-{[4-(1H-benzoimidazol-2-yl)phenylamino]methyl}phenyl)-3-bromo-4-methoxy-benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	2-{2-Methoxy-5-[5-(4-trifluoromethoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	heptasodium (2R,3S,4S,5R,6R)-2-{[(2S,3S,4S,5R,6R)-2-methoxy-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-4-yl]oxy}-4,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-3-yl sulfate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	IC50
	8-(4-Phenyl[1,2,3]triazol-1-yl)octyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->2)-3,4,6-tri-O-sulfo-alpha-D-mannopyranoside, Tridecasodium Salt Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Heparanase Protein (Entity type)	Kd

2-{5-[5-(3,4-Difluoro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

tetradecasodium[(2R,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6R)-6-[(2R,3R,4S,5R,6R)-6-[(2R,3R,4S,5R,6R)-6-[[(4R)-4-[(3S,5S,8R,9S,10S,12S,13R,14S,17R)-12-acetoxy-10,13-dimethyl-3-sulfonatooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-4,5-disulfonatooxy-2-(sulfonatooxymethyl)tetrahydropyran-3-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)tetrahydropyran-4-yl]sulfate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
Ki

2-{5-[5-(3-Chloro-phenyl)-benzooxazol-2-yl]-2-methoxy-phenyl}-1,3-dioxo-indan-5-carboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

3beta-cholestanyl 2,3,4,6-tetra-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranosyl-(1->4)-2,3,6-tri-O-sulfo-beta-D-glucopyranoside, tridecasodium salt
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
Ki

8-(5-Dimethylaminonaphthalene-1-sulfonamido)octyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->2)-3,4,6-tri-O-sulfo-alpha-D-mannopyranoside, Tridecasodium Salt
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
Kd

N-(4-{[4-(1H-benzoimidazol-2-yl)phenylamino]methyl}phenyl)-3-bromo-4-methoxy-benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

2-{2-Methoxy-5-[5-(4-trifluoromethoxy-phenyl)-benzooxazol-2-yl]-phenyl}-1,3-dioxo-indan-5-carboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

heptasodium (2R,3S,4S,5R,6R)-2-{[(2S,3S,4S,5R,6R)-2-methoxy-3,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-4-yl]oxy}-4,5-bis(sulfonatooxy)-6-[(sulfonatooxy)methyl]oxan-3-yl sulfate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
IC50

8-(4-Phenyl[1,2,3]triazol-1-yl)octyl 2,3,4,6-Tetra-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->3)-2,4,6-tri-O-sulfo-alpha-D-mannopyranosyl-(1->2)-3,4,6-tri-O-sulfo-alpha-D-mannopyranoside, Tridecasodium Salt
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Heparanase
Protein (Entity type)
Kd

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