Eukaryotic translation initiation factor 4E (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Eukaryotic translation initiation factor 4E 's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-purin-1-ium-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	Ki
(4-(7-(2-(4-Chlorophenoxy)ethyl)-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl)benzyl)phosphonic Acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
((2R,3S,4R,5R)-5-(2-amino-7-(2-(4-chloro-3-fluorophenoxy)ethyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
1,18-Dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-19,30,33-trimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone;Rapamycin Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	Kd
US9073881, 140 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
((2R,3S,4R,5R)-5-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
US9073881, 15::US9073881, 16 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
((4-(3-(2-(4-Chlorophenoxy)ethyl)-6-(methylamino)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-2-yl)phenyl)difluoromethyl)-phosphonic Acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
4-(7-(2-(4-Chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7Hpurin-8-yl)phenylphosphonic Acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50
US9073881, 80 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Eukaryotic translation initiation factor 4E Protein (Entity type)	IC50

((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxido-9H-purin-1-ium-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
Ki

(4-(7-(2-(4-Chlorophenoxy)ethyl)-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl)benzyl)phosphonic Acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

((2R,3S,4R,5R)-5-(2-amino-7-(2-(4-chloro-3-fluorophenoxy)ethyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

1,18-Dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-19,30,33-trimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.0*4,9*]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone;Rapamycin
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
Kd

US9073881, 140
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

((2R,3S,4R,5R)-5-(2-amino-7-(2-(4-chlorophenoxy)ethyl)-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

US9073881, 15::US9073881, 16
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

((4-(3-(2-(4-Chlorophenoxy)ethyl)-6-(methylamino)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-2-yl)phenyl)difluoromethyl)-phosphonic Acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

4-(7-(2-(4-Chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7Hpurin-8-yl)phenylphosphonic Acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

US9073881, 80
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Eukaryotic translation initiation factor 4E
Protein (Entity type)
IC50

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