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C-X-C chemokine receptor type 4 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View C-X-C chemokine receptor type 4 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	(R,R,R,R,R,R,2R,2'R)-N,N'-((2R,5R,21S,41R,44R)-5,41-bis(4-aminobutyl)-21-carbamoyl-3,6,19,27,40,43-hexaoxo-10,13,16,30,33,36-hexaoxa-4,7,20,26,39,42-hexaazapentatetracontane-2,44-diyl)bis(1-((2R,5R,8R,11R,14R,20R)-5-((1H-imidazol-5-yl)methyl)-8-((1H-indol-3-yl)methyl)-20-amino-2-(3-guanidinopropyl)-11-(hydroxymethyl)-14,22-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazatricosane)pyrrolidine-2-carboxamide) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	3-(2-naphthyl)-1-[3-[[N-(2-naphthyl)carbamimidoyl]amino]propyl]-1-[4-[3-[[N-(2-naphthyl)carbamimidoyl]amino]propylamino]butyl]guanidine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	(R)-1-(3,5-dimethylpyridin-2-yl)-N-methyl-N-((5-(piperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)methanamine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	US9314468, Table 7, Compound 106 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	N-benzyl-N-methyl-4-(piperidin-1-ylmethyl)benzenesulfonamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	3,3-Dimethyl-N1-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-N1-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	(S)-N-((1-(((S)-1-isopropylpiperidin-3-yl)methyl)-1H-benzo[d]imidazol-2-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	(3S,6S,9S,12S,15S,22S)-22-((3S,6S,9S,12R,17R,20S,23S,26S,29R,34aS)-17-((S)-2-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanamido)-3-(naphthalen-2-yl)propanamido)-26,29-bis(4-aminobutyl)-6,9,23-tris(3-guanidinopropyl)-3,20-bis(4-hydroxybenzyl)-1,4,7,10,18,21,24,27,30-nonaoxodotriacontahydropyrrolo[1,2-r][1,2,6,9,12,15,18,21,24,27]dithiaoctaazacyclodotriacontine-12-carboxamido)-1-((S)-1-((S)-2,6-diaminohexanoyl)pyrrolidin-2-yl)-15-(4-hydroxybenzyl)-6,12-bis(hydroxymethyl)-9-isobutyl-3-isopropyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazatricosan-23-oic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	US9314468, Table 8, Compound 15 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50
	2,2',2''-(10-((S)-20-((2R,5S,8S,14R)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-1-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)-11-(2-(3-((2R,5S,8S,14R)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-1-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)propylamino)-2-oxoethylcarbamoyl)-2,9,13,16-tetraoxo-3,10,14,17-tetraazaicosyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	C-X-C chemokine receptor type 4 Protein (Entity type)	IC50

(R,R,R,R,R,R,2R,2'R)-N,N'-((2R,5R,21S,41R,44R)-5,41-bis(4-aminobutyl)-21-carbamoyl-3,6,19,27,40,43-hexaoxo-10,13,16,30,33,36-hexaoxa-4,7,20,26,39,42-hexaazapentatetracontane-2,44-diyl)bis(1-((2R,5R,8R,11R,14R,20R)-5-((1H-imidazol-5-yl)methyl)-8-((1H-indol-3-yl)methyl)-20-amino-2-(3-guanidinopropyl)-11-(hydroxymethyl)-14,22-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazatricosane)pyrrolidine-2-carboxamide)
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

3-(2-naphthyl)-1-[3-[[N-(2-naphthyl)carbamimidoyl]amino]propyl]-1-[4-[3-[[N-(2-naphthyl)carbamimidoyl]amino]propylamino]butyl]guanidine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

(R)-1-(3,5-dimethylpyridin-2-yl)-N-methyl-N-((5-(piperazin-1-yl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)methanamine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

US9314468, Table 7, Compound 106
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

N-benzyl-N-methyl-4-(piperidin-1-ylmethyl)benzenesulfonamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

3,3-Dimethyl-N1-(((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)methyl)-N1-((S)-5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

(S)-N-((1-(((S)-1-isopropylpiperidin-3-yl)methyl)-1H-benzo[d]imidazol-2-yl)methyl)-N-methyl-5,6,7,8-tetrahydroquinolin-8-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

(3S,6S,9S,12S,15S,22S)-22-((3S,6S,9S,12R,17R,20S,23S,26S,29R,34aS)-17-((S)-2-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanamido)-3-(naphthalen-2-yl)propanamido)-26,29-bis(4-aminobutyl)-6,9,23-tris(3-guanidinopropyl)-3,20-bis(4-hydroxybenzyl)-1,4,7,10,18,21,24,27,30-nonaoxodotriacontahydropyrrolo[1,2-r][1,2,6,9,12,15,18,21,24,27]dithiaoctaazacyclodotriacontine-12-carboxamido)-1-((S)-1-((S)-2,6-diaminohexanoyl)pyrrolidin-2-yl)-15-(4-hydroxybenzyl)-6,12-bis(hydroxymethyl)-9-isobutyl-3-isopropyl-1,4,7,10,13,16-hexaoxo-2,5,8,11,14,17-hexaazatricosan-23-oic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

US9314468, Table 8, Compound 15
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

2,2',2''-(10-((S)-20-((2R,5S,8S,14R)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-1-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)-11-(2-(3-((2R,5S,8S,14R)-5-(3-guanidinopropyl)-14-(4-hydroxybenzyl)-1-methyl-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)propylamino)-2-oxoethylcarbamoyl)-2,9,13,16-tetraoxo-3,10,14,17-tetraazaicosyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
C-X-C chemokine receptor type 4
Protein (Entity type)
IC50

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