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Protein Mdm4 (Protein)

Description: A protein in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Protein Mdm4 's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	US8969341, 106 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50
	US8969341, 114 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50
	5-((1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50
	US8815926, 18 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50
	(S)-Methyl-2-(3,3-Diphenylpropanamido)-3-(4-hydroxyphenyl)propanoate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50
	(2S)-2-acetamido-N-[(1S)-2-[[(1S)-4-amino-1-[[(1S)-4-amino-1-[[(1S,2R)-1-[[(1S)-2-[[(3S,6S,9S,12S,15S,18S,21R,28Z,33S)-33-[[(1S)-4-amino-1-[[(1S)-3-amino-1-carbamoyl-3-oxo-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-18-(2-amino-2-oxo-ethyl)-9-(4-guanidinobutyl)-12-(1H-indol-3-ylmethyl)-3,6,15-triisobutyl-21,33-dimethyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotritriacont-28-en-21-yl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-oxo-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanediamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	Kd
	(S)-1-((2R,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,33R)-14-((1H-indol-3-yl)methyl)-32-amino-11-(2-amino-2-oxoethyl)-26-benzyl-20-(2-carboxyethyl)-33-hydroxy-17-(4-hydroxybenzyl)-2-((S)-1-hydroxyethyl)-29-(hydroxymethyl)-5,8-diisobutyl-23-methyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatetratriacontane)pyrrolidine-2-carboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	Kd
	(4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(1S)-3-amino-1-carbamoyl-3-oxopropyl]amino]-5-oxopentanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	Kd
	(3S,6S,9S,12S,15S)-3-((4S,7S,10S,13S,16S)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-4-((S)-2-((S)-1,3-dicarboxypropylcarbamoyl)pyrrolidine-1-carbonyl)-7-isobutyl-2,18-dimethyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecan-16-ylcarbamoyl)-15-amino-9-benzyl-12-((R)-1-hydroxyethyl)-6-(hydroxymethyl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecane-1,18-dioic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	Kd
	(S)-3-(2-(3-Guanidinobenzamido)acetamido)-4-oxo-4-(phenethylamino)butanoic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Protein Mdm4 Protein (Entity type)	IC50

US8969341, 106
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

US8969341, 114
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

5-((1-(4-nitrophenyl)-2,5-diphenyl-1H-pyrrol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

US8815926, 18
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

(S)-Methyl-2-(3,3-Diphenylpropanamido)-3-(4-hydroxyphenyl)propanoate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

(2S)-2-acetamido-N-[(1S)-2-[[(1S)-4-amino-1-[[(1S)-4-amino-1-[[(1S,2R)-1-[[(1S)-2-[[(3S,6S,9S,12S,15S,18S,21R,28Z,33S)-33-[[(1S)-4-amino-1-[[(1S)-3-amino-1-carbamoyl-3-oxo-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-18-(2-amino-2-oxo-ethyl)-9-(4-guanidinobutyl)-12-(1H-indol-3-ylmethyl)-3,6,15-triisobutyl-21,33-dimethyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotritriacont-28-en-21-yl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-4-oxo-butyl]carbamoyl]-4-oxo-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]pentanediamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
Kd

(S)-1-((2R,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,33R)-14-((1H-indol-3-yl)methyl)-32-amino-11-(2-amino-2-oxoethyl)-26-benzyl-20-(2-carboxyethyl)-33-hydroxy-17-(4-hydroxybenzyl)-2-((S)-1-hydroxyethyl)-29-(hydroxymethyl)-5,8-diisobutyl-23-methyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazatetratriacontane)pyrrolidine-2-carboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
Kd

(4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-acetamido-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(1S)-3-amino-1-carbamoyl-3-oxopropyl]amino]-5-oxopentanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
Kd

(3S,6S,9S,12S,15S)-3-((4S,7S,10S,13S,16S)-13-((1H-indol-3-yl)methyl)-10-(4-aminobutyl)-4-((S)-2-((S)-1,3-dicarboxypropylcarbamoyl)pyrrolidine-1-carbonyl)-7-isobutyl-2,18-dimethyl-6,9,12,15-tetraoxo-5,8,11,14-tetraazanonadecan-16-ylcarbamoyl)-15-amino-9-benzyl-12-((R)-1-hydroxyethyl)-6-(hydroxymethyl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaoctadecane-1,18-dioic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
Kd

(S)-3-(2-(3-Guanidinobenzamido)acetamido)-4-oxo-4-(phenethylamino)butanoic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Protein Mdm4
Protein (Entity type)
IC50

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