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topotecan (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View topotecan's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	topotecan Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Camptothecin Compound (Entity type)	0.8619877696037292
	topotecan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SCAND1 Gene (Entity type)	0.015166153
	topotecan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DDB2 Gene (Entity type)	0.02362716
	SIB-1893 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	topotecan Compound (Entity type)	0.649643063545227
	idarubicin Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	topotecan Compound (Entity type)	0.7601781487464905
	Skatole Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	topotecan Compound (Entity type)	0.2292077988386154
	topotecan Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	DNA topoisomerase 1 Protein (Entity type)	IC50
	topotecan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KRT17 Gene (Entity type)	0.01940039
	topotecan Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TFPI Gene (Entity type)	-0.014963841
	topotecan Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LGALS3BP Gene (Entity type)	0.018518724

topotecan
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Camptothecin
Compound (Entity type)
0.8619877696037292

topotecan
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SCAND1
Gene (Entity type)
0.015166153

topotecan
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DDB2
Gene (Entity type)
0.02362716

SIB-1893
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
topotecan
Compound (Entity type)
0.649643063545227

idarubicin
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
topotecan
Compound (Entity type)
0.7601781487464905

Skatole
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
topotecan
Compound (Entity type)
0.2292077988386154

topotecan
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
DNA topoisomerase 1
Protein (Entity type)
IC50

topotecan
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KRT17
Gene (Entity type)
0.01940039

topotecan
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TFPI
Gene (Entity type)
-0.014963841

topotecan
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LGALS3BP
Gene (Entity type)
0.018518724

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