2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
Dacarbazine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	0.4678970277309418
safrolglycol Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	0.3088769018650055
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RERE Gene (Entity type)	-0.003430359
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A2 Gene (Entity type)	0.004243904
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-2A adrenergic receptor Protein (Entity type)	Ki
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	LY-2886721 Compound (Entity type)	0.5317740440368652
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C1 Gene (Entity type)	-0.0063587897
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RBP1 Gene (Entity type)	0.0041986983
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SEMA3C Gene (Entity type)	-0.0038474805
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A7 Gene (Entity type)	0.0039738207

Dacarbazine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
0.4678970277309418

safrolglycol
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
0.3088769018650055

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RERE
Gene (Entity type)
-0.003430359

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A2
Gene (Entity type)
0.004243904

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-2A adrenergic receptor
Protein (Entity type)
Ki

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
LY-2886721
Compound (Entity type)
0.5317740440368652

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AKR1C1
Gene (Entity type)
-0.0063587897

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RBP1
Gene (Entity type)
0.0041986983

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SEMA3C
Gene (Entity type)
-0.0038474805

2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester (Yohimbine)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A7
Gene (Entity type)
0.0039738207

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