1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LTF Gene (Entity type)	-0.006333508
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-1B adrenergic receptor Protein (Entity type)	Ki
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GASK1B Gene (Entity type)	-0.0033852411
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C2 Gene (Entity type)	-0.0043653925
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PIK3C2B Gene (Entity type)	0.0044687013
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SPON1 Gene (Entity type)	0.004318383
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AKR1C3 Gene (Entity type)	-0.004816218
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FXR1 Gene (Entity type)	-0.0031600583
1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Phenprocoumon Compound (Entity type)	0.3373088240623474
Phenprocoumon Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	1-[3-(4,4-diphenylhexahydro-1-pyridinyl)propyl] 3-methyl 4,6-dimethyl-2-phenyl(3-nitro)-3,6-cyclohexadiene-1,3-dicarboxylate (niguldipine) Compound (Entity type)	0.3373088240623474