(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ABHD4 Gene (Entity type)	-0.005404564
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TCL1A Gene (Entity type)	0.0052120606
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PEG10 Gene (Entity type)	-0.0069949413
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	VEGFA Gene (Entity type)	-0.0050943103
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	JNK inhibitor IX Compound (Entity type)	0.4017646610736847
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CHAC1 Gene (Entity type)	-0.0052844533
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CRYAB Gene (Entity type)	0.0060396674
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	UCP2 Gene (Entity type)	-0.0052711237
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100A12 Gene (Entity type)	0.006429328
(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Metabotropic glutamate receptor 2 Protein (Entity type)	EC50

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ABHD4
Gene (Entity type)
-0.005404564

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TCL1A
Gene (Entity type)
0.0052120606

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PEG10
Gene (Entity type)
-0.0069949413

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
VEGFA
Gene (Entity type)
-0.0050943103

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
JNK inhibitor IX
Compound (Entity type)
0.4017646610736847

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CHAC1
Gene (Entity type)
-0.0052844533

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CRYAB
Gene (Entity type)
0.0060396674

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
UCP2
Gene (Entity type)
-0.0052711237

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100A12
Gene (Entity type)
0.006429328

(-)-(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Metabotropic glutamate receptor 2
Protein (Entity type)
EC50

DISPLAY PER PAGE

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
Loading results...

DISPLAY PER PAGE

CFDE Workbench

Consortium

Community

Resources

@CFDE Workbench 2025

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.