isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LYN Gene (Entity type)	0.0064036264
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ALCAM Gene (Entity type)	0.0045008548
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Potassium voltage-gated channel subfamily H member 2 Protein (Entity type)	IC50
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ALDH2 Gene (Entity type)	-0.0039009068
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DLK1 Gene (Entity type)	0.005389603
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ATF3 Gene (Entity type)	-0.005200323
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRAPPC3 Gene (Entity type)	-0.006029898
KU-C104139 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	0.2191442251205444
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL13 Gene (Entity type)	-0.00410059
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SCGB2A1 Gene (Entity type)	0.0045739803

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LYN
Gene (Entity type)
0.0064036264

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ALCAM
Gene (Entity type)
0.0045008548

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Potassium voltage-gated channel subfamily H member 2
Protein (Entity type)
IC50

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ALDH2
Gene (Entity type)
-0.0039009068

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DLK1
Gene (Entity type)
0.005389603

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ATF3
Gene (Entity type)
-0.005200323

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRAPPC3
Gene (Entity type)
-0.006029898

KU-C104139
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
0.2191442251205444

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL13
Gene (Entity type)
-0.00410059

isopropyl 4-(1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SCGB2A1
Gene (Entity type)
0.0045739803

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