(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RHOBTB3 Gene (Entity type)	-0.00448746
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AMDHD2 Gene (Entity type)	0.0039925887
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DIPK1A Gene (Entity type)	0.004794451
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	S100P Gene (Entity type)	0.004298247
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ZBTB20 Gene (Entity type)	-0.0036230404
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA2 Gene (Entity type)	-0.0037368054
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	miglitol Compound (Entity type)	0.312583178281784
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	TG-100115 Compound (Entity type)	0.2804329693317413
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RPS4Y1 Gene (Entity type)	-0.004810051
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MT1G Gene (Entity type)	0.004603918

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RHOBTB3
Gene (Entity type)
-0.00448746

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AMDHD2
Gene (Entity type)
0.0039925887

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DIPK1A
Gene (Entity type)
0.004794451

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
S100P
Gene (Entity type)
0.004298247

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ZBTB20
Gene (Entity type)
-0.0036230404

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PHLDA2
Gene (Entity type)
-0.0037368054

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
miglitol
Compound (Entity type)
0.312583178281784

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
TG-100115
Compound (Entity type)
0.2804329693317413

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RPS4Y1
Gene (Entity type)
-0.004810051

(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MT1G
Gene (Entity type)
0.004603918

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