8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	C14orf132 Gene (Entity type)	-0.0033130571
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LMO2 Gene (Entity type)	-0.0033162844
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	COL18A1 Gene (Entity type)	-0.0035724826
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	LY-317615 Compound (Entity type)	0.3106392025947571
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CST1 Gene (Entity type)	-0.0035038255
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NCF4 Gene (Entity type)	0.0034455862
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Mitogen-activated protein kinase kinase kinase 8 Protein (Entity type)	IC50
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RGS5 Gene (Entity type)	-0.003493887
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GULP1 Gene (Entity type)	-0.003610557
8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SEZ6L2 Gene (Entity type)	-0.003401502

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
C14orf132
Gene (Entity type)
-0.0033130571

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LMO2
Gene (Entity type)
-0.0033162844

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
COL18A1
Gene (Entity type)
-0.0035724826

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
LY-317615
Compound (Entity type)
0.3106392025947571

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CST1
Gene (Entity type)
-0.0035038255

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NCF4
Gene (Entity type)
0.0034455862

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Mitogen-activated protein kinase kinase kinase 8
Protein (Entity type)
IC50

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RGS5
Gene (Entity type)
-0.003493887

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GULP1
Gene (Entity type)
-0.003610557

8-chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SEZ6L2
Gene (Entity type)
-0.003401502

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