2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	STEAP1 Gene (Entity type)	-0.0066474318
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	MGP Gene (Entity type)	0.0052100755
PD-325901 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	0.8428844213485718
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	FAM3C Gene (Entity type)	-0.0066350726
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DNAJB2 Gene (Entity type)	0.004824353
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SLPI Gene (Entity type)	0.0058608833
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Casein kinase II subunit alpha Protein (Entity type)	IC50
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	REEP1 Gene (Entity type)	0.004892032
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AKR1C2 Gene (Entity type)	0.0057816543
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PHLDA2 Gene (Entity type)	-0.008393846

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
STEAP1
Gene (Entity type)
-0.0066474318

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
MGP
Gene (Entity type)
0.0052100755

PD-325901
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
0.8428844213485718

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
FAM3C
Gene (Entity type)
-0.0066350726

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DNAJB2
Gene (Entity type)
0.004824353

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SLPI
Gene (Entity type)
0.0058608833

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Casein kinase II subunit alpha
Protein (Entity type)
IC50

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
REEP1
Gene (Entity type)
0.004892032

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AKR1C2
Gene (Entity type)
0.0057816543

2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PHLDA2
Gene (Entity type)
-0.008393846

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