2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Chronic heart failure Disease or Phenotype (Entity type)
oseltamivir-phosphate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	0.1662448793649673
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RTN2 Gene (Entity type)	-0.004294097
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PERP Gene (Entity type)	0.0031503423
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLC7A5 Gene (Entity type)	-0.0036863424
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	ADGRG2 Gene (Entity type)	-0.003949955
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	OLFM4 Gene (Entity type)	0.00439984
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IKZF1 Gene (Entity type)	-0.0035656837
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD40 Gene (Entity type)	-0.003491614
PCA 4248 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril) Compound (Entity type)	0.2320155948400497

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Chronic heart failure
Disease or Phenotype (Entity type)

oseltamivir-phosphate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
0.1662448793649673

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RTN2
Gene (Entity type)
-0.004294097

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PERP
Gene (Entity type)
0.0031503423

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLC7A5
Gene (Entity type)
-0.0036863424

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
ADGRG2
Gene (Entity type)
-0.003949955

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
OLFM4
Gene (Entity type)
0.00439984

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IKZF1
Gene (Entity type)
-0.0035656837

2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD40
Gene (Entity type)
-0.003491614

PCA 4248
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (quinapril)
Compound (Entity type)
0.2320155948400497

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Knowledge Graph Assertions

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