4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GCLM Gene (Entity type)	0.012996686
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	0.7962539196014404
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Proteasome subunit beta type-1 Protein (Entity type)	IC50
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SH3BGRL Gene (Entity type)	-0.0109001435
((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	0.4899446666240692
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	H2AC25 Gene (Entity type)	-0.01198148
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	XYLT1 Gene (Entity type)	-0.0127776805
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Compound (Entity type)	0.7962539196014404
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SATB2 Gene (Entity type)	-0.012731048
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TSPAN4 Gene (Entity type)	-0.012014475

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GCLM
Gene (Entity type)
0.012996686

(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
0.7962539196014404

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Proteasome subunit beta type-1
Protein (Entity type)
IC50

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SH3BGRL
Gene (Entity type)
-0.0109001435

((1S,2S,4R)-4-(4-((S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
0.4899446666240692

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
H2AC25
Gene (Entity type)
-0.01198148

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
XYLT1
Gene (Entity type)
-0.0127776805

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Compound (Entity type)
0.7962539196014404

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SATB2
Gene (Entity type)
-0.012731048

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TSPAN4
Gene (Entity type)
-0.012014475

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