(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	gemifloxacin Compound (Entity type)	0.4661030769348144
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLAT Gene (Entity type)	0.0036918866
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	HIV Infections Disease or Phenotype (Entity type)
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	paracetamol Compound (Entity type)	0.4184716045856476
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SCD Gene (Entity type)	-0.005796899
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TARBP1 Gene (Entity type)	0.0034401356
Cefoperazone Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	0.4238994121551513
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Y-27152 Compound (Entity type)	0.4189878106117248
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	IGFBP5 Gene (Entity type)	-0.004608004
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCP4 Gene (Entity type)	0.004337366

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
gemifloxacin
Compound (Entity type)
0.4661030769348144

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLAT
Gene (Entity type)
0.0036918866

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
HIV Infections
Disease or Phenotype (Entity type)

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
paracetamol
Compound (Entity type)
0.4184716045856476

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SCD
Gene (Entity type)
-0.005796899

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TARBP1
Gene (Entity type)
0.0034401356

Cefoperazone
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
0.4238994121551513

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Y-27152
Compound (Entity type)
0.4189878106117248

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
IGFBP5
Gene (Entity type)
-0.004608004

(S)-Efavirenz; (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCP4
Gene (Entity type)
0.004337366

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