N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ADO Gene (Entity type)	0.0072511607
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AREG Gene (Entity type)	0.008020889
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase Chk1 Protein (Entity type)	IC50
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	amsacrine Compound (Entity type)	0.4036333560943603
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NEAT1 Gene (Entity type)	-0.0066036233
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cyclic GMP-AMP synthase Protein (Entity type)	IC50
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HSPA1A Gene (Entity type)	-0.01067755
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RELB Gene (Entity type)	0.008540557
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TFPI2 Gene (Entity type)	0.0074037993
N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CDC20 Gene (Entity type)	-0.008617579

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ADO
Gene (Entity type)
0.0072511607

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AREG
Gene (Entity type)
0.008020889

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase Chk1
Protein (Entity type)
IC50

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
amsacrine
Compound (Entity type)
0.4036333560943603

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NEAT1
Gene (Entity type)
-0.0066036233

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cyclic GMP-AMP synthase
Protein (Entity type)
IC50

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HSPA1A
Gene (Entity type)
-0.01067755

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RELB
Gene (Entity type)
0.008540557

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TFPI2
Gene (Entity type)
0.0074037993

N-(3-(5-iodo-4-(3-(thiophene-2-carboxamido)propylamino)pyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CDC20
Gene (Entity type)
-0.008617579

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