Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Serine/threonine-protein kinase mTOR Protein (Entity type)	IC50
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NAT1 Gene (Entity type)	-0.014754154
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	RAB5IF Gene (Entity type)	-0.014507873
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Compound (Entity type)	0.775840163230896
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CSRP2 Gene (Entity type)	-0.015258606
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PFN2 Gene (Entity type)	-0.014596294
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TM4SF1 Gene (Entity type)	0.016083607
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	S100A8 Gene (Entity type)	-0.01791845
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	DAPK1 Gene (Entity type)	0.017133463
Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	HMGA1 Gene (Entity type)	0.01303815

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Serine/threonine-protein kinase mTOR
Protein (Entity type)
IC50

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NAT1
Gene (Entity type)
-0.014754154

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
RAB5IF
Gene (Entity type)
-0.014507873

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
Compound (Entity type)
0.775840163230896

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CSRP2
Gene (Entity type)
-0.015258606

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PFN2
Gene (Entity type)
-0.014596294

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TM4SF1
Gene (Entity type)
0.016083607

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
S100A8
Gene (Entity type)
-0.01791845

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
DAPK1
Gene (Entity type)
0.017133463

Methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-morpholin-4-yl-1Hpyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
HMGA1
Gene (Entity type)
0.01303815

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