4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PFKFB3 Gene (Entity type)	-0.005480963
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GBP2 Gene (Entity type)	-0.0049196677
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LTF Gene (Entity type)	0.005629915
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CCNB1 Gene (Entity type)	0.0038436328
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TRAPPC3 Gene (Entity type)	-0.004353713
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	AGT Gene (Entity type)	0.0040507605
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CXCL8 Gene (Entity type)	-0.004349986
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Activin receptor type-1B Protein (Entity type)	Kd
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCLAF Gene (Entity type)	0.005081245
4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TGFBR2 Gene (Entity type)	0.0045651156

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PFKFB3
Gene (Entity type)
-0.005480963

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GBP2
Gene (Entity type)
-0.0049196677

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LTF
Gene (Entity type)
0.005629915

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CCNB1
Gene (Entity type)
0.0038436328

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TRAPPC3
Gene (Entity type)
-0.004353713

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
AGT
Gene (Entity type)
0.0040507605

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CXCL8
Gene (Entity type)
-0.004349986

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Activin receptor type-1B
Protein (Entity type)
Kd

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCLAF
Gene (Entity type)
0.005081245

4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TGFBR2
Gene (Entity type)
0.0045651156

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