3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Alpha-2B adrenergic receptor Protein (Entity type)	Ki
n-nitrosodiethylamine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	0.2762776017189026
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	5-hydroxytryptamine receptor 1A Protein (Entity type)	Ki
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KIF20A Gene (Entity type)	0.003704671
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TOB1 Gene (Entity type)	-0.0041297176
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MT1E Gene (Entity type)	-0.00580921
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Potassium voltage-gated channel subfamily H member 2 Protein (Entity type)	IC50
Carbenoxolone Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	0.3521045446395874
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Mixed bipolar I disorder Disease or Phenotype (Entity type)
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KRT14 Gene (Entity type)	-0.0042399485

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Alpha-2B adrenergic receptor
Protein (Entity type)
Ki

n-nitrosodiethylamine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
0.2762776017189026

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
5-hydroxytryptamine receptor 1A
Protein (Entity type)
Ki

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KIF20A
Gene (Entity type)
0.003704671

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TOB1
Gene (Entity type)
-0.0041297176

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MT1E
Gene (Entity type)
-0.00580921

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Potassium voltage-gated channel subfamily H member 2
Protein (Entity type)
IC50

Carbenoxolone
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
0.3521045446395874

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Mixed bipolar I disorder
Disease or Phenotype (Entity type)

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KRT14
Gene (Entity type)
-0.0042399485

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