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Donepezil (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View Donepezil's neighborhood in the knowledge graph.

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
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@CFDE Workbench 2024

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

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Tools & Use Cases

The CFDE Workbench is actively being developed and maintained by the CFDE Data Resource Center (DRC).The DRC is funded by OT2OD036435 from the Common Fund at the National Institutes of Health.

@CFDE Workbench 2024

Knowledge Graph Assertions

	Source	Relation	Target	Evidence
	Donepezil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ZIC1 Gene (Entity type)	0.002921617
	Donepezil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	ABLIM1 Gene (Entity type)	0.002856201
	Donepezil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GLUL Gene (Entity type)	0.003209558
	Donepezil Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Alzheimer's Disease Disease or Phenotype (Entity type)
	Donepezil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	STK10 Gene (Entity type)	-0.0036019066
	Donepezil Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Beta-secretase 1 Protein (Entity type)	IC50
	Donepezil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	HOXB6 Gene (Entity type)	-0.0026445533
	Donepezil Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KRT8 Gene (Entity type)	-0.0033420552
	Donepezil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	RGCC Gene (Entity type)	0.0038698812
	Donepezil Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	OXA1L Gene (Entity type)	0.0030609532

Donepezil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ZIC1
Gene (Entity type)
0.002921617

Donepezil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
ABLIM1
Gene (Entity type)
0.002856201

Donepezil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GLUL
Gene (Entity type)
0.003209558

Donepezil
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Alzheimer's Disease
Disease or Phenotype (Entity type)

Donepezil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
STK10
Gene (Entity type)
-0.0036019066

Donepezil
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Beta-secretase 1
Protein (Entity type)
IC50

Donepezil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
HOXB6
Gene (Entity type)
-0.0026445533

Donepezil
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KRT8
Gene (Entity type)
-0.0033420552

Donepezil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
RGCC
Gene (Entity type)
0.0038698812

Donepezil
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
OXA1L
Gene (Entity type)
0.0030609532

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