IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SELENOP Gene (Entity type)	0.0025360547
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	LTF Gene (Entity type)	0.0037233832
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase TXK Protein (Entity type)	IC50
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	GDF15 Gene (Entity type)	-0.004237327
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase JAK3 Protein (Entity type)	IC50
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	AREG Gene (Entity type)	-0.007187298
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Tyrosine-protein kinase Fgr Protein (Entity type)	IC50
TWS119 Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	0.3736509680747986
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Indication Knowledge Graph Relation (Entity type)	Chronic graft-versus-host disease Disease or Phenotype (Entity type)
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1 Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DUSP5 Gene (Entity type)	-0.004696059

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SELENOP
Gene (Entity type)
0.0025360547

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
LTF
Gene (Entity type)
0.0037233832

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase TXK
Protein (Entity type)
IC50

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
GDF15
Gene (Entity type)
-0.004237327

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase JAK3
Protein (Entity type)
IC50

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
AREG
Gene (Entity type)
-0.007187298

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Tyrosine-protein kinase Fgr
Protein (Entity type)
IC50

TWS119
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
0.3736509680747986

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Indication
Knowledge Graph Relation (Entity type)
Chronic graft-versus-host disease
Disease or Phenotype (Entity type)

IBRUTINIB::US9108973, Ref 1::US9181263, 1::US9278100, 1
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DUSP5
Gene (Entity type)
-0.004696059

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Knowledge Graph Assertions

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