3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)'s neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MT2A Gene (Entity type)	-0.007485722
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	trimetozine Compound (Entity type)	0.2679053544998169
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CD55 Gene (Entity type)	-0.0058578863
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KRT14 Gene (Entity type)	0.0075287786
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CEACAM5 Gene (Entity type)	0.0063072625
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	LRRC17 Gene (Entity type)	-0.00751794
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINB5 Gene (Entity type)	0.010100969
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	MXI1 Gene (Entity type)	-0.00648742
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	GPX2 Gene (Entity type)	0.0071324063
3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone) Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TGFB1 Gene (Entity type)	-0.007006624

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MT2A
Gene (Entity type)
-0.007485722

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
trimetozine
Compound (Entity type)
0.2679053544998169

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CD55
Gene (Entity type)
-0.0058578863

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KRT14
Gene (Entity type)
0.0075287786

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CEACAM5
Gene (Entity type)
0.0063072625

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
LRRC17
Gene (Entity type)
-0.00751794

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINB5
Gene (Entity type)
0.010100969

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
MXI1
Gene (Entity type)
-0.00648742

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
GPX2
Gene (Entity type)
0.0071324063

3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-2-methyl-pyrido[1,2-a]pyrimidin-4-one (Pirenperone)
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TGFB1
Gene (Entity type)
-0.007006624

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