3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide (Compound)

Description: A compound in the knowledge graph

Analyze

CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide's neighborhood in the knowledge graph.

Submit

Knowledge Graph Assertions

Source	Relation	Target	Evidence
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KRT6A Gene (Entity type)	-0.02039614
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EMP1 Gene (Entity type)	-0.024454402
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Ponatinib Compound (Entity type)	0.5596975684165955
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PCK2 Gene (Entity type)	0.019446878
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL20 Gene (Entity type)	-0.020418772
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	KDM5D Gene (Entity type)	0.018860321
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TMPRSS3 Gene (Entity type)	0.016624382
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	F3 Gene (Entity type)	-0.019323079
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CBS Gene (Entity type)	0.025498055
3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	S100A10 Gene (Entity type)	-0.017632658

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KRT6A
Gene (Entity type)
-0.02039614

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EMP1
Gene (Entity type)
-0.024454402

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Ponatinib
Compound (Entity type)
0.5596975684165955

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PCK2
Gene (Entity type)
0.019446878

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL20
Gene (Entity type)
-0.020418772

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
KDM5D
Gene (Entity type)
0.018860321

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TMPRSS3
Gene (Entity type)
0.016624382

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
F3
Gene (Entity type)
-0.019323079

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CBS
Gene (Entity type)
0.025498055

3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
S100A10
Gene (Entity type)
-0.017632658

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