N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SERPINA1 Gene (Entity type)	0.0254686
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	SFRP4 Gene (Entity type)	0.030517297
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	EPHB2 Gene (Entity type)	-0.020992877
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CPM Gene (Entity type)	0.027870348
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SLN Gene (Entity type)	-0.02521354
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Dinaciclib Compound (Entity type)	0.4122141599655151
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	KLHL41 Gene (Entity type)	-0.022862444
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SRGN Gene (Entity type)	-0.028558873
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Cyclin-dependent kinase 7 Protein (Entity type)	IC50
N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CHRDL1 Gene (Entity type)	0.026440874

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SERPINA1
Gene (Entity type)
0.0254686

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
SFRP4
Gene (Entity type)
0.030517297

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
EPHB2
Gene (Entity type)
-0.020992877

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CPM
Gene (Entity type)
0.027870348

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SLN
Gene (Entity type)
-0.02521354

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Dinaciclib
Compound (Entity type)
0.4122141599655151

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
KLHL41
Gene (Entity type)
-0.022862444

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SRGN
Gene (Entity type)
-0.028558873

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Cyclin-dependent kinase 7
Protein (Entity type)
IC50

N-(3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CHRDL1
Gene (Entity type)
0.026440874

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