1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	CCL20 Gene (Entity type)	-0.0090566045
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	TRIP6 Gene (Entity type)	0.0052691437
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one Compound (Entity type)	0.399019181728363
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	NFKB2 Gene (Entity type)	-0.005853695
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Ephrin type-A receptor 2 Protein (Entity type)	Kd
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Oxatomide Compound (Entity type)	0.3788699805736542
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	S100A8 Gene (Entity type)	-0.009742087
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	BHLHE41 Gene (Entity type)	-0.005847926
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	SRC Gene (Entity type)	-0.010700126
1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	PLBD1 Gene (Entity type)	0.0060924306

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
CCL20
Gene (Entity type)
-0.0090566045

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
TRIP6
Gene (Entity type)
0.0052691437

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
4-[(S)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-3-(4-methyl-6-morpholin-4-yl-1H-benzoimidazol-2-yl)-1H-pyridin-2-one
Compound (Entity type)
0.399019181728363

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
NFKB2
Gene (Entity type)
-0.005853695

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Ephrin type-A receptor 2
Protein (Entity type)
Kd

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Oxatomide
Compound (Entity type)
0.3788699805736542

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
S100A8
Gene (Entity type)
-0.009742087

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
BHLHE41
Gene (Entity type)
-0.005847926

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
SRC
Gene (Entity type)
-0.010700126

1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
PLBD1
Gene (Entity type)
0.0060924306

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