(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine (Compound)

Description: A compound in the knowledge graph

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CFDE DD-Knowledge Graph

The CFDE Data Distillery Knowledge Graph contains entities and relationships across the CFDE. View (S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine's neighborhood in the knowledge graph.

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Knowledge Graph Assertions

Source	Relation	Target	Evidence
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	CSTA Gene (Entity type)	0.0061762454
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	THBS2 Gene (Entity type)	-0.0033556875
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Positively regulates Knowledge Graph Relation (Entity type)	NUSAP1 Gene (Entity type)	0.0065513765
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	DDAH1 Gene (Entity type)	-0.0037318126
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	PLAAT3 Gene (Entity type)	-0.004398771
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	SB-683698 Compound (Entity type)	0.3674514889717102
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Negatively regulates Knowledge Graph Relation (Entity type)	TNS3 Gene (Entity type)	-0.0044769226
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	Bioactivity Knowledge Graph Relation (Entity type)	Beta-secretase 1 Protein (Entity type)	IC50
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	Metamizole Compound (Entity type)	0.3364302217960357
(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine Compound (Entity type)	In similarity relationship with Knowledge Graph Relation (Entity type)	zonisamide Compound (Entity type)	0.3448939025402069

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
CSTA
Gene (Entity type)
0.0061762454

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
THBS2
Gene (Entity type)
-0.0033556875

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Positively regulates
Knowledge Graph Relation (Entity type)
NUSAP1
Gene (Entity type)
0.0065513765

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
DDAH1
Gene (Entity type)
-0.0037318126

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
PLAAT3
Gene (Entity type)
-0.004398771

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
SB-683698
Compound (Entity type)
0.3674514889717102

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Negatively regulates
Knowledge Graph Relation (Entity type)
TNS3
Gene (Entity type)
-0.0044769226

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
Bioactivity
Knowledge Graph Relation (Entity type)
Beta-secretase 1
Protein (Entity type)
IC50

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
Metamizole
Compound (Entity type)
0.3364302217960357

(S)-4-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Compound (Entity type)
In similarity relationship with
Knowledge Graph Relation (Entity type)
zonisamide
Compound (Entity type)
0.3448939025402069

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