PR002251 (Project)

Id Namespace:

UCSD Metabolomics Workbench

Identifier Namespace (Entity type)

Dcc Asset:

MW submission packet 20250922.zip

Processed File (Entity type)

Dcc:

Metabolomics

DCC (Entity type)

Persistent Id:http://dx.doi.org/10.21228/M8NV72

Description:Study used single nuclei genomics techniques to examine the spatial transcriptional function of the transcription factor 7-like 2 (TCF7L2) in rodent liver. Research aimed to determine the consequences of TCF7L2 transcriptional inactivation on the metabolic architecture of the liver, and on the function of key zonated metabolic pathways that influence the development of fibrotic liver diseases. Dietary stress was investigated using the Gubra Amylin Nash (GAN) and choline-deficient amino acid-defined high fat (CDAHFD) diets to investigate the susceptibility of liver-specific TCF7L2 mutant mice (Hep-TCF7L2ΔDBD) compared to control (TCF7L2LoxP/LoxP) mice in hepatic fibrosis.

Results found

Linked to

	Label	Description
	PPR00001 Project (Entity type)	Metabolomics
	SU003771 Subject (Entity type)	A subject from Metabolomics produced as part of the PR002251 project
	SA397806 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397766 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397786 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397799 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397762 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397776 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397772 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project
	SA397785 Biosample (Entity type)	A biosample from Metabolomics produced as part of the PR002251 project

PPR00001

Project (Entity type)

Metabolomics

SU003771

Subject (Entity type)

A subject from Metabolomics produced as part of the PR002251 project

SA397806

Biosample (Entity type)